​the science
human clinical trials using cannabis for autism

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Human Clinical Trials

• Oral Cannabidiol Use in Children with Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities (Israel 2019)

• Real Life Experience of Medical Cannabis Treatment in Autism:  Analysis of Safety and Efficacy (Israel 2019)

• Cannabidiol Based Medicine in Children with Autism - A Retrospective Feasibility Study (Israel 2018)

• Oral Cannabis Extracts as a Promising Treatment for the Core Symptoms of Autism Spectrum Disorder:  Preliminary Experience in Chilean Patients  (Chile, 2017)

• Use of Dronabinol (delta-9-THC) in Autism:  A prospective single-case-study with an Early Infantile Autistic Child​ (Austria 2010)

• An Open Label Study of the Use of Dronabinol (Marinol) in the Management of Treatment-Resistant Self-Injurious Behavior in 10 Retarded Adolescent Patients (USA 2006)   (contact MAMMA for a PDF of this abstract)

• ​Use of Dronabinol (delta-9-thc) in Autism:  A Prospective Single-Case-Study with an Early Infantile Autistic Child (Austria 2010)

Literature Reviews

• Medical Cannabis for Autism Spectrum Disorder, Is it an Option (USA 2019)

Related Research

• Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling ​

• Can Autism be Triggered by Acetaminophen Activation of the Endocannabinoid System? 

• ​​Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders ​

• ​​Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders

• ​evidence for a common endocannabinoid-related pathomechanism in autism spectrum disorders

• the in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages

• The Endocannabinoid System in Normal and Pathological Brain Ageing (2012)